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Gene expression Investigation uncovered that ACKR3 is highly expressed in several brain areas corresponding to significant opioid action facilities. In addition, its expression concentrations are sometimes better than These of classical opioid receptors, which additional supports the physiological relevance of its noticed in vitro opioid peptide sc
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These final results, along with a past report showing that a small-molecule ACKR3 agonist CCX771 displays anxiolytic-like habits in mice,2 aid the concept of targeting ACKR3 as a unique strategy to modulate the opioid program, which could open new therapeutic avenues for opioid-related Problems.Importantly, these receptors had been identified to ha